RXR alpha, aa111-228, Recombinant, Human (Retinoid X Receptor alpha)

The retinoid X receptor(RXR) is a pleiotropic nuclear receptor transcription factor that interacts with a variety of nuclear receptor dimeric partner. RXR binds cognate response elements as a homodimer in the presence of its ligand, 9-cis retinoic acid, or as a heterodimer with other members of the nuclear hormone receptor superfamily including retinoic acid receptors(RAR), thyroid hormone receptors(TR), vitamin D receptors and peroxisome proliferators-activated receptors(PPAR). The RXR family includes three difference isoforms ; RXR alpha, beta, gamma. Human RXR a gene is localized on 9q34.9 and encodes two major isoforms(RXR a1, RXR a2).\n\nDescription: \nRecombinant Human RXR-a produced in E.Coli is a single, non-glycosylated polypeptide chain containing 119 amino acids & having a molecular mass of 13.6kD. The DNA binding domain of RXR(111-228aa) was purified by using conventional column chromatography techniques.\n\nSequence: \nMLGLNGVLKV PAHPSGNMAS FTKHICAICG DRSSGKHYGV YSCEGCKGFF KRTVRKDLTY TCRDNKDCLI DKRQRNRCQY CRYQKCLAMG MKREAVQEER QRGKDRNENE VESTSSANE\n\nStability: \nStore at 4 degrees C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degrees C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

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SPECIFICATIONS

Catalog Number

R9985-01

Size

10ug

Form

Supplied as a liquid in 20mM Tris-HCl, pH 7.5, 0.1M sodium chloride, 5mM beta-Mercaptoethanol.

Purity

(same/more than) 95% as determined by RP-HPLC, anion-exchange FPLC and/or reducing and non-reducing SDS-PAGE Silver Stained gel.

References

1. Regulation of retinoic acid receptors alpha, beta and retinoid X receptor alpha after sciatic nerve injury.\n\nNeuroscience 2006 Jun 16;\n\n2. Hypericum sampsonii induces apoptosis and nuclear export of retinoid X receptor-alpha.\n\nCarcinogenesis 2006 Apr 18;\n\n3. A structure-based approach to retinoid X receptor-alpha inhibition.\n\nJ Biol Chem 2006 Jun 16;281(24):16643-8\n\n4. 9-cis-retinoic acid up-regulates expression of transcriptional coregulator PELP1, a novel coactivator of the retinoid X receptor alpha pathway.\n\nJ Biol Chem 2006 Jun 2;281(22):15394-404\n\n5. Nuclear export of retinoid X receptor alpha in response to interleukin-1beta-mediated cell signaling: roles for JNK and SER260.\n\nJ Biol Chem 2006 Jun 2;281(22):15434-40\n\n6. Identification and characterization of the human retinoid X receptor alpha gene promoter.\n\nGene 2006 May 10;372:118-27