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(S,S)-Palonosetron Hydrochloride

(S,S)-Palonosetron Hydrochloride

Cat no: 019101

Supplier: United States Biological
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Serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic Melting Point: >280 degrees C (dec) Specific Rotation: -113 degrees (c = 0.65; water) Solubility: Methanol, Water Method for Determining Identity: Proton NMR (CD3OD) spectroscopic analysis and mass spectrometric analysis TLC Conditions: SiO2; Dichlormethane : Methanol : Ammonium Hydroxide (5: 5 : 1). Visualized with UV and and KMno4 (single spot; Rf= 0.70). Storage and Stability: Stored at 4 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Catalogue number: 019101
Size: 10mg
Form: White Solid
Purity: ~98%
Alternative names: (3aS)-2-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one Hydrochloride; Aloxi; Onicit; RS-25259-197
References: Clark, R.D., et al.: J. Med. Chem., 36, 2645 (1993), Wong, E.H.F., et al.: Br. J. Pharmacol., 114, 851 (1995), Grunberg, S.M., et al.: Expert. Opin. Pharmacother., 4, 2297 (2003), Eisenberg, P., et al.: Ann. Oncol., 15, 330 (2004), Siddiqui, M.A.A., et al.: Drugs, 64, 1125 (2004),

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