S100A11 (S6) (Protein S100-A11, S100 Calcium-binding Protein A11, Protein S100C, Calgizzarin,Metastatic Lymph Node Gene 70 Protein, MLN 70, S100C)

S100A11 is a 10-12kD member of the S100 family, EF-hand superfamily of Ca-binding proteins. It is produced by smooth muscle and keratinocytes. Intracellularly, it suppresses growth; extracellularly, it exists as both a monomer, homodimer, and heterodimer with S100B, binds to RAGE, induces EGF, and promotes cell growth. Human S100A11 is 105aa in length. It contains two EF-hand motifs aa13-49, 55-90 and one high-affinity Ca- binding site aa68-79, and binds annexin I with its C-terminal half. There may be one alternative splice form that apparently contains a series of mutations over aa61-79 and shows 90aa identity to the standard form. Full-length human S100A11 shares 78-82aa identity with mouse and porcine S100A11, respectively.\n\nApplications:\nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 2ug/ml\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

S0051-88G

Size

100ug

Hosts

Mouse

Form

Supplied as a lyophilized powder in PBS, trehalose. Reconstitute with sterile PBS to 0.5mg/ml.

P Type

Mab

Purity

Purified by Protein A/G affinity chromatography.

Isotype

IgG2B

Additional Info

Recognizes human S100A11. No cross-reactivity with recombinant human S100A1, A2, A4, A6, A7, A8, A9, A10, A13, rhS100B, rhS100P, recombinant mouse S100A1, A4, A6, A8, A9, A10, A11, A13, or A16.