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SAP18, Recombinant, Human (SIN3-Associated Protein, p18, 2HOR0202)

Cat no: S0094-01

SAP18, Recombinant, Human (SIN3-Associated Protein, p18, 2HOR0202)

SAP18, also known as Sin3A-associated protein, which includes Sin3 (protein with four putative paired amphipathic helix domains), HDCA1 and HDCA2, is component of the histone deacetylase complex that plays an important role in the regulation of eukaryotic gene expression. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. It also has been shown to play a key role in gene-specific recruitment of the HDAC complex by a number of transcription factors including Gli, GAGA, and Bicoid.\n\nSource:\nRecombinant SAP18 protein was expressed in E.coli and purified by using conventional chromatography techniques.\n\nMolecular Weight:\n19.7 kD(173 aa).\n\nAA Sequence:\nMGSSHHHHHH SSGLVPRGSH MAVESRVTQE EIKKEPEKPI DREKTCPLLL RVFTTNNGRH HRMDEFSRGN VPSSELQIYT WMDATLKELT SLVKEVYPEA RKKGTHFNFA IVFTDVKRPG YRVKEIGSTM SGRKGTDDSM TLQSQKFQIG DYLDIAITPP NRAPPPSGRM RPY\n\n\nStorage and Stability:\nFor long-term storage, aliquot and store at -20 degrees C/-70 degrees C. Aliquots are stable for at least 6 months at -20 degrees C/-70 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.\n\n\n

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SPECIFICATIONS

Catalog Number

S0094-01

Size

100ug

Form

Supplied as a liquid in 20mM Tris-HCl buffer, pH8.0, containing 0.1M NaCl,\n30% glycerol, 1mM DTT.\n

Purity

~90% by SDS-PAGE.

References

Zhang Y., et al. (1997) Cell. 89(3):357-64. Matyash A, et al. (2009) J Biol Chem. 284(5):3012-20.\n

Alternative Names

2HOR0202, SAP18P

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SUPPLIER INFO

Applications

ELISA

Reactivities

Hum

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Applications

IF

Hosts

Mouse

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Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

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Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

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Applications

ELISA, FC, IHC, WB

Hosts

Mouse

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Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

More info

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

More info

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