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SB 431542

Cat no: S0999

SB 431542

SB 431542 is a potent and selective inhibitor of the TGF-b1 receptor ALK5 (IC50 = 94 nM)1. It is a less potent antagonist of ALK4 (IC50 = 140 nM)2 and ALK7.3 It does not affect the BMP receptors ALK2, ALK3, ALK6, or a panel of other kinases tested.3 SB 431542 specifically blocks Smad signaling, reducing gene expression relevant to fibrosis and cancer.3 Through its effects on ALK/Smad signaling, SB 431542 suppresses renewal in embryonic and induced pluripotent stem cells and promotes their differentiation.4,5\n\nSolubility:\nDMSO: 10 mg/ml, soluble\nH2O: insoluble\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Reconstitute to nominal volume and store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

S0999

Size

10mg

Form

Supplied as a crystalline solid.

Purity

(same/more than) 98% (HPLC)

References

1 Callahan, J.F., Burgess, J.L., Fornwald, J.A., et al. Identification of novel inhibitors of the transforming growth factor b1 (TGF-b1) type 1 receptor (ALK5). J Med Chem 45(5) 999-1001 (2002).\n2 Laping, N.J., Grygielko, E., Mathur, A., et al. Inhibition of Transforming Growth Factor (TGF)-b1-Induced Extracellular Matrix with a Novel Inhibitor of the TGF-b Type I Receptor Kinase Activity: SB-431542. Mol Pharmacol 62(1) 58-64 (2002).\n3 Inman, G.J., Nicol

Alternative Names

4-(5-Benzol[1,3]dioxol-5-yl-4-pyrldin-2-yl-1H-imidazol-2-yl)-benzamide hydrate, 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]-benzamide hydrate, 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide hydrate

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