Supplier:
Alomone Labs Ltd.Cat no: STS-370
Scyllatoxin
A Potent Blocker of K\\Ca\\2 (SK) K+ Channels.
Scyllatoxin is a 31 amino acid long toxin, originally isolated from the Leiurus quinquestriatus hebraeus scorpion venom, and is classified as alpha-KTx 5.1 scorpion toxin family, having three disulfide bridges.
Scyllatoxin was shown to compete with \\125\\I -apamin binding in the brain. Furthermore, Scyllatoxin appears to be selective for apamin-sensitive SK channels.
Scyllatoxin inhibits apamin-sensitive SK channel activity in guinea-pig and rabbit hepatocytes, SK currents in human lymphoblastoma cells, and epinephrine-induced relaxation of visceral smooth muscle.
Scyllatoxin also inhibits the apamin-sensitive after hyperpolarization that follows action potentials in skeletal muscle and neurons.
The SK channel-mediated after hyperpolarising current (I\\AHP\\) of dorsal vagal neurons, presuming K\\Ca\\2.3 (SK3), were blocked by Scyllatoxin (20пїЅ30 nM). HEK 293 cell currents stably expressing hK\\Ca\\2.1 (hSK1) and K\\Ca\\2.2 (hSK2) were blocked by Scyllatoxin with anпїЅIC50 of 80 nM and 287 pM, respectively.
Alomone Labs is pleased to offer Scyllatoxin (#STS-370), a highly potent blocker of K\\Ca\\ channels with highest affinity towards K\\Ca\\2.2, having the following affinities: K\\Ca\\2.2 < < K\\Ca\\2.3 < K\\Ca\\2.1.
Ion Channel Modulators; K+ Channel Blockers
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SPECIFICATIONS
Catalog Number
STS-370
Size
5 x 0.1 mg
Purity
>98%
Concentration
20-200 nM.
Shipping Temp
Room Temperature
Molecular Weight
3423 da
SUPPLIER INFO
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