Secretin (SCT)

Glucagon is a member of a multigene family comprising of Secretin, Vasoactive Intestinal Peptide (VIP), Gastric Inhibitory Peptide (GIP) and others like Glicentin and Oxyntomodulin (OXM), which differs from glucagon by C-terminal octapeptide. The glucagon precursor contains at least 3 intervening sequences that divide the protein-coding portion into 4 regions corresponding to the signal peptide and part of the N-terminal peptide, the remainder of the N-terminal peptide and glucagon, glucagon-like peptide-1 (GLP1), and GLP2. SECR, Secretin is a 27aa hormone (chr 11p15) produced by specific endocrine cells, S cells, located in the mucosa of the proximal small intestine. It has been known to be a potent stimulus for the secretion of bicarbonate-rich pancreatic juice. Secretion of secretin is stimulated by the presence of either acidic pH or fatty acids in the duodenum. Secretin stimulates ductal bile secretion by directly interacting with cholangiocytes, promotes osmotic water movement in cholangiocytes by inducing the exocytic insertion of AQP1 into plasma membranes.\n\nApplications:\nSuitable for use in ELISA. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:5,000 \nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Reconstitute with sterile ddH2O, sterile 40-50% glycerol, aliquot and store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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