Secretory Component Glycoprotein (Secretory Component p85, Extracellular matrix protein 1, ECM1, ECM-1, Epithelial Transport Receptor)

Secretory Component Glycoprotein is an epithelial transport receptor for polymeric IgA and IgM. Antibody to secretory component has been shown to be useful for identifying glandular carcinomas. Defects in Secretory Component Glycoprotein are the cause of lipoid proteinosis (LiP), also known as lipoid proteinosis of Urbach and Wiethe or hyalinosis cutis et mucosae. LiP is a rare autosomal recessive disorder characterized by generalized thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness. Histologically, there is widespread deposition of hyaline material and disruption/reduplication of basement membrane.\n\nApplications: \nSuitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilutions:\nWestern Blot: 1:1000\nImmunoprecipitation: 1:50\nImmunohistochemistry (Frozen, paraffin): 1:200\nOptimal dilutions to be determined by the researcher.\n\nPositive Controls: \nSecretory mucosa of gastrointestinal and respiratory tract, Epithelia of salivary glands, Endometrium, Endocervix, Kidney, Prostate, Mammary gland\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

S0630-05A

Size

100ug

Applications

IHC, IP, WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.4, 15mM sodium azide.

P Type

Mab

Purity

Purified by affinity chromatography.

Isotype

IgG1

References

1. Bartek J et al. Keratin 19 expression in the adult and developing human mammary gland. Histochem J 22:537-44 (1990). 2. Bartek J et al. Secretory component in differentiating normal epithelium, benign lesions and malignancy in the human breast as monitored by monoclonal antibodies. Histochemistry 91:235-44 (1989). 3. Kvale D et al. Rapid selection of cultured cells with increased expression of a membrane marker (secretory component). Int J Cancer 42:638-41 (1988).

Additional Info

Recognizes 80kD human secretory component glycoprotein (both free and bound in secretory IgA).