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Semagacestat

Cat no: 020894


Supplier: United States Biological
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Semagacestat is an inhibitor of the g-secretase enzyme. g-Secretase enzyme is pivotal in the generation of b-amyloid (Ab), a neurotoxic endogenous peptide believed to be involved in the pathogenesis of Alzheimer's disease (AD). Form: White Solid Melting Point: 214-216 degrees C Solubility: DMSO, Methanol
Catalogue number: 020894
Size: 10mg
Form: White Solid
Alternative names: (2S)-2-Hydroxy-3-methyl-N-[(1S)-1-methyl-2-oxo-2-[[(1S)-2,3,4,5-tetrahydro-3-methyl-2-oxo-1H-3-benzazepin-1-yl]amino]ethyl]butanamide; LY 450139;
References: Portelius, E. et al.: Alzheim. Res. Ther., 22. No pp. given (2010); Imbimbo, B.P. et al.: Curr. Opin. Invest. Drugs, 10, 721 (2009); Panza, F. et al.: Curr. Med. Chem., 18, 5430 (2011);

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