SENP2 (Sentrin-specific protease 2) is a protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Downregulates CTNNB1 levels and thereby modulates the Wnt pathway.
Sequence:
The peptidase domain of mouse SENP2 (aa 394-588) is fused at the N-terminus to a His-tag.
Storage and Stability:
Short-term Storage: +4 degrees C
Long-term Storage: -20 degrees C
Working aliquots are stable for up to 3 months when stored at -20 degrees C.