Serpin A1, Human, BioAssay(TM) DuoSet ELISA Development Kit (A1AT, alpha 1-Antitrypsin, alpha 1-Proteinase Inhibitor)

The human serpin superfamily consists of 35 members that target not only serine proteases, but also selected cysteine proteases and non-protease proteins. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. They are also involved in activities that extend beyond their ability to inhibit proteases. For instance, they may also regulate blood pressure, angiogenesis, or act as storage/transport proteins.\n\nSample Type:\nCell culture supernates\n\nIntended Use:\nThis BioAssay(TM) DuoSet ELISA Development kit contains the basic components required for the development of sandwich ELISAs to measure natural and recombinant human Serine Peptidase Inhibitor clade A member 1 (Serpin A1). DuoSets are designed for the analysis of cell culture supernates. \n\nRange:\n~125-8000pg/ml\n\nSpecificity:\nRecognizes natural and recombinant human Serine Peptidase Inhibitor clade A member 1 (Serpin A1). \n\nKit Components:\nGoat anti-human Serpin A1 capture antibody, 1x vial\nBiotinylated goat anti-human Serpin A1 detection antibody, 1x vial\nRecombinant human Serpin A1 standard, 3x vials\nStreptavidin-HRP, 1x vial\n\nStorage and Stability:\nStore other components at 4 degrees C. Stable for at least 6 months For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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