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Serum, Human, HAMA (Human anti-Mouse Antibody)

Cat no: S1010-40

Serum, Human, HAMA (Human anti-Mouse Antibody)

HAMA or Human Anti-Mouse Antibody is a human antibody produced in reaction to the presence of foreign (or mouse) antibody. The original Kohler and Milstein technology provided rodent monoclonal antibodies to any antigen to which the animals could be immunised. These have been used therapeutically and the first monoclonal antibody to be licensed for therapy by the FDA was OrthoClone OKT3 a mouse IgG2a (FDA approved 1986). Rodent antibodies tend to provoke strong Human anti-Murine Antibody (HAMA) immune responses which restricts their usefulness for repeated application in the same patient.

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SPECIFICATIONS

Catalog Number

S1010-40

Size

1ml

References

http://www.path.cam.ac.uk/~mrc7/humanisation/index.html

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