Home  >  Products  >  SF3B4 (Splicing Factor 3B Subunit 4, Pre-mRNA-splicing Factor SF3b 49kD Subunit, SF3b50, Spliceosome-associated Protein 49, SAP 49, SAP49)
SF3B4 (Splicing Factor 3B Subunit 4, Pre-mRNA-splicing Factor SF3b 49kD Subunit, SF3b50, Spliceosome-associated Protein 49, SAP 49, SAP49)

SF3B4 (Splicing Factor 3B Subunit 4, Pre-mRNA-splicing Factor SF3b 49kD Subunit, SF3b50, Spliceosome-associated Protein 49, SAP 49, SAP49)

Cat no: S5555-50J

Supplier: United States Biological
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The SF3B4 gene encodes one of four subunits of the splicing factor 3B. The protein encoded by this gene cross-links to a region in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A. It also may be involved in the assembly of the B, C and E spliceosomal complexes. In addition to RNA-binding activity, this protein interacts directly and highly specifically with subunit 2 of the splicing factor 3B. This protein contains two N-terminal RNA-recognition motifs (RRMs), consistent with the observation that it binds directly to pre-mRNA. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:32,000 Western Blot: 0.1-0.3ug/ml, observed in human HeLa lysates on ~48kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S5555-50J
Reactivities: Human, Mouse, Rat, Bovine, Canine, Porcine
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Yamasaki S, Ishikawa E, Sakuma M, Hara H, Ogata K, Saito T. Mincle is an ITAM-coupled activating receptor that senses damaged cells. Nat Immunol. 2008 Oct;9(10):1179-88. 2. Friend K, Lovejoy AF, Steitz JA. U2 snRNP binds intronless histone pre-mRNAs to facilitate U7-snRNP-dependent 3' end formation. Mol Cell. 2007 Oct 26;28(2):240-52.
Additional info: Recognizes human SF3B4. Species sequence homology: Bovine, canine, mouse, porcine and rat.

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