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sFRP-5, Recombinant, Human (Secreted Frizzled-related Protein 5, Frizzled-related Protein 1b, FRP-1b, Secreted Apoptosis-related Protein 3, SARP3)

sFRP-5, Recombinant, Human (Secreted Frizzled-related Protein 5, Frizzled-related Protein 1b, FRP-1b, Secreted Apoptosis-related Protein 3, SARP3)

Cat no: 045278

Supplier: United States Biological
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Soluble frizzled-related proteins (sFRPs) are modulators of Wnt signaling through direct interaction with Wnts. They regulate cell growth and differentiation in specific cell types. sFRP-5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity. It is secreted by adipocytes and controls the microenvironment of white adipose tissue under conditions of metabolic stress. After secretion sFRP-5 sequesters Wnt5a, preventing noncanonical pathway activation. In the obesity state, adipocytes enlarge and secrete more Wnt5a but less sFRP-5. Macrophages present in the obese adipose tissue respond to Wnt5a excess and produce proinflammatory cytokines that lead to insulin resistance. sFRP-5 was also suggested to be involved in determining the polarity of photoreceptor cells in the retina. Sequence: Signal peptide and human sFRP-5 (aa 1-317) is fused at the C-terminus to a FLAG-tag. Storage and Stability: Short-term Storage: +4 degrees C Long-term Storage: -20 degrees C Working aliquots are stable for up to 3 months when stored at -20 degrees C.
Catalogue number: 045278
Size: 10ug
Form: Supplied as a liquid from a 0.2um-filtered solution in PBS, pH 7.2.
Purity: >90% (SDS-PAGE)
Alternative names: Secreted Frizzled-related Protein 5, Frizzled-related Protein 1b, FRP-1b, Secreted Apoptosis-related Protein 3, SARP3

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