Supplier:
Alomone Labs Ltd.Cat no: F-130
sFTX-3.3
Polyamine amide spider toxins inhibit neuronal voltage-activated Ca2+ currents.пїЅA terminal arginine group is an important feature of these Ca2+ channel antagonists.
FTX is a polyamine component of the venom of the American funnel web spider Agelenopsis aperta, and has been described as a selective antagonist of P-type voltage-dependent Ca2+ channels. However, it has been demonstrated that FTX has actions at other sites including NMDA and GABA receptors and also on T-type calcium channels.
sFTX-3.3, a synthetic funnel web spider toxin, is a polyamine amide analogue of FTX. The structures of these polyamine containing compounds are not identical: sFTX-3.3 contains an amide carbonyl oxygen that is absent from the predicted structure of native FTX. sFTX-3.3 has been shown to block P-type calcium channels in rat cerebellar Purkinje cells and antagonizes P-, N-, and L-type calcium channels in mammalian Purkinje and superior cervical ganglia neurons with similar potencies; Its IC50 against P-, N-, and L-type channels are ~0.24 mM, ~0.7 mM and ~0.7 mM, respectively.
Alomone Labs is pleased to offer sFTX-3.3 (#F-130).
Ion Channel Modulators; Voltage - Gated Ca2+ Channel Blockers.
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SPECIFICATIONS
Catalog Number
F-130
Size
1 mg
Purity
>95%
Concentration
0.1-1 mM
Shipping Temp
Room Temperature
Molecular Weight
287.4 da
SUPPLIER INFO
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