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SGCD, Recombinant, Human, aa57-289, His-Tag (Delta-sarcoglycan, 35DAG, CMD1L, DAGD, SG-delta, SGCDP, SGD)

Cat no: 137207

SGCD, Recombinant, Human, aa57-289, His-Tag (Delta-sarcoglycan, 35DAG, CMD1L, DAGD, SG-delta, SGCDP, SGD)

SGCD is one of the four known components of the sarcoglycan complex, which is a subcomplex of the dystrophin-glycoprotein complex (DGC). DGC forms a link between the F-actin cytoskeleton and the extracellular matrix. This protein is expressed most abundantly in skeletal and cardiac muscle. The mutations in this gene have been associated with autosomal recessive limb-girdle muscular dystrophy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding distinct isoforms have been observed. In melanocytic cells SGCD gene expression may be regulated by MITF. \n\nSource: \nRecombinant protein corresponding to human SGCD, fused to His-tag at N-terminal expressed in E.coli.\n\nMolecular Weight: \n~28kD (257aa)\n\nAA Sequence:\nMGSSHHHHHH SSGLVPRGSH RSHMKVMNFT IDGMGNLRIT EKGLKLEGDS EFLQPLYAKE IQSRPGNALY FKSARNVTVN ILNDQTKVLT QLITGPKAVE AYGKKFEVKT VSGKLLFSAD NNEVVVGAER LRVLGAEGTV FPKSIETPNV RADPFKELRL ESPTRSLVME APKGVEINAE AGNMEATCRT ELRLESKDGE IKLDAAKIRL PRLPHGSYTP TGTRQKVFEI CVCANGRLFL SQAGAGSTCQ INTSVCL\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

137207

Size

100ug

Form

Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, 0.4M urea, 10% glycerol.

Purity

~85% (SDS-PAGE)

References

1. Sylvius N, Duboscq-Bidot L, et al. (2003). Am J Med Genet A. 120A(1):8-12.

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