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SH2D1A, Recombinant, Human (SH2 Domain-containing Protein 1A, Duncan Disease SH2-protein, Signaling Lymphocytic Activation Molecule-associated Protein, SLAM-associated Protein T-cell Signal Transduction Molecule SAP, DSHP, SAP)

Cat no: S1013-31E4

SH2D1A, Recombinant, Human (SH2 Domain-containing Protein 1A, Duncan Disease SH2-protein, Signaling Lymphocytic Activation Molecule-associated Protein, SLAM-associated Protein T-cell Signal Transduction Molecule SAP, DSHP, SAP)

SH2D1A is an inhibitor of the signaling lymphocyte activation molecule (SLAM) self-association. This protein is expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Defects in SH2D1A are a cause of X-linked lymphoproliferative disease (XLPD) also known as Duncan disease. XLPD is characterized by a rare congenital immunodeficiency following Epstein-Barr virus (EBV) infection.\n\nSource:\nRecombinant corresponding to aa1-128 of human SH2D1A protein, fused to His-tag at N-terminus, expressed in E.coli.\n\nAA Sequence:\nMGSSHHHHHH SSGLVPRGSH MDAVAVYHGK ISRETGEKLL LATGLDGSYL LRDSESVPGV YCLCVLYHGY IYTYRVSQTE TGSWSAETAP GVHKRYFRKI KNLISAFQKP DQGIVIPLQY PVEKKSSARS TQGTTGIRED PDVCLKAP\n\nMolecular Weight: 16.3kD (148aa) confirmed by MALDI-TOF\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

S1013-31E4

Size

100ug

Form

Supplied as a liquid in 20mM Tris-HCl, pH 7.5, 1mM DTT, 10% glycerol.

Purity

~95% (SDS-PAGE).

References

1. Schwartzberg PL., et al. (2010) Immunity. 32(2):253-65. 2. Lenardo MJ., et al (2009) J Clin Invest. 119(10):2976-89.

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