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Sheep anti Human Factor V polyclonal antibody [FITC]

Cat no: CABT-L416

Sheep anti Human Factor V polyclonal antibody [FITC]

Sheep Anti-Human Factor V polyclonal antibody for IEP, ELISA. Factor V (formerly referred to as accelerator globulin and labile factor) is a large glycoprotein (320 kDa) that is produced in the liver. The gene that encodes factor V (F.V) is located on chromosome 1. A congenital deficiency of F.V is a hemorrhagic disorder inherited as an autosomal recessive disease. The concentration of F.V in plasma is typically 10 ?g/mL. F.V is a pro-cofactor that is activated through limited proteolysis by thrombin, or by activated factor X in the presence of phospholipid surface. Other physiologic activators of F.V include plasmin, neutrophil elastase and platelet calpain. The activated cofactor (F.Va) is an essential component of the prothrombin activator complex, which consists of F.Va, activated factor X, calcium and anionic phospholipid surface. The intact prothrombinase complex activates prothrombin to thrombin at a rate 300,000-fold greater than activated factor X alone. In a positive feedback loop, the thrombin generated accelerates its own generation by activating more F.V to F.Va. Thrombin also acts to down-regulate F.Va indirectly by activating Protein C, which inactivates F.Va cofactor activity.

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SPECIFICATIONS

Catalog Number

CABT-L416

Applications

ELISA

Hosts

Sheep

Reactivities

Hum

Target

F5

Gene Id

2153

Isotype

IgG

Clonality

Polyclonal

Storage Temp

Store at 2В°C to 8В°C and protect from light.

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