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SHP 1 (SHP1, SHP-1, Hematopoietic Cell Protein-tyrosine Phosphatase, HCP, HCPH, Protein-tyrosine Phosphatase 1C, PTP1C, PTP-1C, HPTP1C, Protein-tyrosine Phosphatase SHP-1, SH-PTP1, SHP-1L, Tyrosine-protein Phosphatase Non-receptor Type 6, PTPN6)

Cat no: S1013-25M

SHP 1 (SHP1, SHP-1, Hematopoietic Cell Protein-tyrosine Phosphatase, HCP, HCPH, Protein-tyrosine Phosphatase 1C, PTP1C, PTP-1C, HPTP1C, Protein-tyrosine Phosphatase SHP-1, SH-PTP1, SHP-1L, Tyrosine-protein Phosphatase Non-receptor Type 6, PTPN6)

SHP-1, an SH2 domain-containing protein tyrosine phosphatase, is primarily expressed in hematopoietic cells and behaves as a key regulator controlling intracellular phosphotyrosine levels in lymphocytes. SHP-1 has been proposed as a candidate tumor suppressor gene in lymphoma, leukemia and other cancers, as it functions as an antagonist to the growth-promoting and oncogenic potentials of tyrosine kinase. Dysfunction in SHP-1 regulation causes abnormal cell growth and induces different kinds of cancers. human SHP-1 gene is located on chromosome 12p13, consists of 17 exons and spans approximately 17 kb of DNA with a transcription size of 2.4

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SPECIFICATIONS

Catalog Number

S1013-25M

Size

100ug

Applications

IHC

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Chengyu, W. et al. Gene. 306:1-12 (2003).

Additional Info

Recognizes human SHP-1. Species crossreactivity: mouse and rat.

Alternative Names

Protein Tyrosine Phosphatase, Non-receptor Type 6, EC=3.1.3.48

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