Home  >  Products  >  SHP 2 (Shp2, SHP-2, SHPTP2, SH-PTP2, BPTP3, CFC, MGC14433, NS1, Tyrosine-protein Phosphatase Non-receptor Type 11, PTPN11, Protein-tyrosine Phosphatase 1D, PTP-1D, Protein-tyrosine Phosphatase 2C, PTP2C, PTP-2C, SH-PTP3)
SHP 2 (Shp2, SHP-2, SHPTP2, SH-PTP2, BPTP3, CFC, MGC14433, NS1, Tyrosine-protein Phosphatase Non-receptor Type 11, PTPN11, Protein-tyrosine Phosphatase 1D, PTP-1D, Protein-tyrosine Phosphatase 2C, PTP2C, PTP-2C, SH-PTP3)

SHP 2 (Shp2, SHP-2, SHPTP2, SH-PTP2, BPTP3, CFC, MGC14433, NS1, Tyrosine-protein Phosphatase Non-receptor Type 11, PTPN11, Protein-tyrosine Phosphatase 1D, PTP-1D, Protein-tyrosine Phosphatase 2C, PTP2C, PTP-2C, SH-PTP3)

Cat no: S1013-29U

Supplier: United States Biological
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The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. SHP-2 contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of SHP-2 with its substrates. The protein is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. The gene for human SHP-2 is mapped to 12q24. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 Immunohistochestry (paraffin): 1:50-1:100 Optimal dilutions to be determined by the researcher. Positive Control: NIH/3T3 cells Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S1013-29U
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: Protein Tyrosine Phosphatase, Non-receptor Type 11, EC=3.1.3.48
References: 1. Saxton, TM. et al. Nat. Genet. 24:420-423 (2000).
Additional info: Recognizes human SHP-2. Species crossreactivity: mouse and rat.

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