Siah-2 (E266) Peptide

Cat no: BS2425P

Supplier: Bioworld Technology, Inc.

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SIAH-2 (seven in absentia homolog 2) is an E3 ligase that catalyzes ubiquitination and proteasome-mediated degradation of protein substrates. SIAH-2 encodes a 324 amino acid protein that shares 77% identity with human SIAH-1 and 68% identity with the Drosophila sina (seven in absentia) gene, on which development of the Drosophila R7 photoreceptor is dependent. SIAH-2 targets TRAF2 (which regulates cell responses to stress and cytokines through the regulation of key stress-signaling cascades) for degradation under stress conditions such as hypoxia. It targets HIF-1alpha prolyl hydroxylase 3 (PHD3) for degradation upon exposure to hypoxic conditions, which coincides with an increase in SIAH-2 transcription. SIAH-2 can decrease TNF-alpha-dependent induction of JNK activity and transcriptional activation of NFkB. SIAH-2 null mice subjected to hypoxia display an impaired respiratory response and reduced levels of hemoglobin.

Catalogue number:	BS2425P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	O43255
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide Siah-2 (E266). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	SIAH1; HUMSIAH. Siah-1. Siah-1a. hSIAH1
Additional info:	This peptide can be used with studies using BS2425 Siah-2 (E266) pAb.

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Siah-2 (E266) Peptide

Cat no: BS2425P

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