Home  >  Products  >  SIGLEC12 (Sialic Acid-binding Ig-like Lectin 12, Siglec-12, Sialic Acid-binding Ig-like Lectin-Like 1, Siglec-L1, SIGLEC12, SIGLECL1, SLG, UNQ9215/PRO34042)
SIGLEC12 (Sialic Acid-binding Ig-like Lectin 12, Siglec-12, Sialic Acid-binding Ig-like Lectin-Like 1, Siglec-L1, SIGLEC12, SIGLECL1, SLG, UNQ9215/PRO34042)

SIGLEC12 (Sialic Acid-binding Ig-like Lectin 12, Siglec-12, Sialic Acid-binding Ig-like Lectin-Like 1, Siglec-L1, SIGLEC12, SIGLECL1, SLG, UNQ9215/PRO34042)

Cat no: S1013-66E

Supplier: United States Biological
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Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. SIGLEC12 is a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. This protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:128,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S1013-66E
Reactivities: Human
Hosts: Goat
Applications: ELISA
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Yu Z, Lai CM, Maoui M, Banville D, Shen SH. Identification and characterization of S2V, a novel putative siglec that contains two V set Ig-like domains and recruits protein-tyrosine phosphatases SHPs. J Biol Chem. 2001 Jun 29;276(26):23816-24.
Additional info: Recognizes SIGLECL1. Species sequence homology: Human.

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