SIN-1 chloride (3-Morpholinosydnonimine, Linsidomine)

Nitric oxide (NO) donor. Generates both superoxide anion and nitric oxide that spontaneously form peroxynitrite. Platelet aggregation inhibitor. Guanylyl cyclase activator. Cytotoxic. Positive ionotropic. Vasodilator.\n\nStorage and Stability:\nShort-term Storage: +4 degrees C\nLong-term Storage: -20 degrees C\nStable for at least 2 years after receipt when stored at -20 degrees C.

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

045283

Size

10mg

Purity

>98% (NMR)

References

Product Reference: \n?Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide: N. Hogg et al.; Biochem. J. 281 , 419 (1992) \n?Inhibition of platelet aggregation and stimulation of guanylate cyclase by an antianginal agent molsidomine and its metabolites: M. Nishikawa et al.; J. Phar.macol. Exp. Ther. 220, 183 (1982) \n?Synergistic platelet antiaggregatory effects of the adenylate cyclase activator iloprost and the guanylate cyclase activating agent SIN-1 in vivo: M. Spiecker, et al.; Thromb. Res. 70, 405 (1993)\n?SIN-1 cytotoxicity to PC12 cells is mediated by thiol-sensitive short-lived substances generated through SIN-1 decomposition in culture medium: K. Konishi, et al.; Nitric Oxide 20, 270 (2009)\n?cAMP-independent activation of protein kinase A by the peroxynitrite generator SIN-1 elicits positive inotropic effects in cardiomyocytes: M.J. Kohr, et al.; J. Mol. Cell. Cardiology 48, 645 (2010)\n?Response of coronary arteries to nitrates, the EDRF-donor SIN-1, and calcium antagonists: W. Schulz & G. Kober; Basic Res. Cardiol. 86, 233 (1991)\n?

Alternative Names

3-Morpholinosydnonimine, Linsidomine