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SIRP-(alpha)1 (R479) pAb

SIRP-(alpha)1 (R479) pAb

Cat no: BS1324

Supplier: Bioworld Technology, Inc.
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SIRPs (signal-regulatory proteins) are a family of transmembrane glycoproteins that were identified by their association with the Src homology 2 domaincontaining protein-tyrosine phosphatase SHP-2 in response to insulin. The SIRP family negatively regulates the PI 3-K pathway, which may diminish EGFR-mediated motility and survival phenotypes that contribute to transformation of certain cell types. SIRP-(alpha)1 is a transmembrane protein which contains an extracellular portion with three immunoglobulin-like structures and a cytoplasmic region with four potential tyrosine phosphorylation sites. SIRP-(alpha)1 is a substrate for activated receptor tyrosine kinases. In its tyrosine phosphorylated form, SIRP-(alpha)1 binds to SH-PTP2 through SH2 interactions and acts as an SH-PTP2 substrate. SIRP-(alpha)1 has been shown to have negative regulatory effects on cellular responses induced by growth factors, oncogenes and insulin. SIRP-(beta)1 shares extensive sequence homology with SIRP-(alpha)1 in its extracellular portion but lacks the cytoplasmic portion. SIRP-(gamma), originally designated SIRP-(beta)2 (SIRP-B2, CD172g) has unique characteristics from both the (alpha) and (beta) versions.
Catalogue number: BS1324
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P78324
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 450-500 of Human SIRP-(alpha)1.
Species: Sirp (alpha)1 (R479) pAb detects endogenous levels of Sirp (alpha)1 protein.
Molecular weight: ~ 55 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: SIRPA; BIT; CD172A; MFR; MYD-1; MYD1; P84; PTPNS1; SHPS-1; SHPS1; SIRP; SIRP-ALPHA-1; SIRP-ALPHA-2; SIRPALPHA; SIRPALPHA2
Additional info: For research use only, not for use in diagnostic procedure.

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