SIRT1 (1F3) Antibody

Cat no: 253046

Supplier: ABBIOTEC

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Description
Additional Information

SIRT1 (NAD-dependent deacetylase sirtuin-1) has been found to associate with the tumor suppressor protein p53. SIRT1 binds and deacetylates p53 with specificity for its C-terminal Lys382 residue in response to the upregulation of promyelocytic leukemia protein (PML) nuclear bodies or oncogenic Ras. The deacetylation of p53 SIRT1 has been shown to negatively regulate p53-mediated transcription,Porcinereventing cellular senescence and apoptosis induced by DNA damage and stress. SIRT1 has the closest homology to the yeast Sir2p and is widely e, Xenopus/Amphibian,pressed in fetal and adult tissues, with high e, Xenopus/Amphibian,pression in heart, brain, skeletal muscle and low e, Xenopus/Amphibian,pression in lung and placenta. SIRT1 regulates the p53-dependent DNA damage response pathway by binding to and deacetylating p53, specifically at Lysine 382.

Catalogue number:	253046
Reactivities:	Human, Mouse
Applications:	Immunofluorescence, Immunohistochemistry
Size:	0.1 ml
Accession:	Q96EB6
Antigen:	Purified recombinant fragment of human SIRT1 e, Xenopus/Amphibian,pressed in E. coli.
Format:	Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
P type:	Mouse Monoclonal Antibody
Isotype:	Mouse IgG1
Clonality:	1F3
Additional info:	NAD-dependent deacetylase sirtuin-1; hSIRT1; SIR2-like protein 1; hSIR2; SIR2L1; SIRT1