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Sirtinol (Sir Two Inhibitor Naphthol, 2-N-(1-phenethyl)benzamide)

Cat no: 045284

Sirtinol (Sir Two Inhibitor Naphthol, 2-N-(1-phenethyl)benzamide)

Specific cell permeable SIRT1 (sirtuin-1) inhibitor. Senescence-like growth arrest inducer. Platelet aggregation inhibitor. Apoptosis inducer.\n\nStorage and Stability:\nShort-term Storage: +4 degrees C\nLong-term Storage: +4 degrees C\nStable for at least 2 years after receipt when stored at +4 degrees C.

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SPECIFICATIONS

Catalog Number

045284

Size

1mg

Purity

>98% (NMR)

References

Product Reference: \n?Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening: C.M. Grozinger, et al.; J. Biol. Chem. 276, 38837 (2001) \n?Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors: A. Mai, et al.; J. Med. Chem. 48, 7789 (2005)\n?Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells: H. Ota, et al.; Oncogene 25, 176 (2006)\n?A new insight of anti-platelet effects of sirtinol in platelets aggregation via cyclic AMP phosphodiesterase: F.C. Liu, et al.; Biochem. Pharmacol. 77, 1364 (2009)\n?SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2: B. Peck, et al.; Mol. Cancer Ther. 9, 844 (2010)\n?

Alternative Names

Sir Two Inhibitor Naphthol, 2--N-(1-phenethyl)benzamide

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