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Sirtuin 2, Recombinant, Human (His) (SIRT2, NAD-dependent Deacetylase Sirtuin-2, SIR2-like protein 2, SIR2L2)

Sirtuin 2, Recombinant, Human (His) (SIRT2, NAD-dependent Deacetylase Sirtuin-2, SIR2-like protein 2, SIR2L2)

Cat no: 045294

Supplier: United States Biological
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Sirtuin 2 (SIRT2) is a NAD-dependent protein deacetylase, which deacetylates the 'Lys-40' of alpha-tubulin. It is involved in the control of mitotic exit in the cell cycle. Furthermore, a variety of age-associated diseases such as type 2 diabetes, obesity, osteoporosis, and Alzheimer's disease are associated with sirtuins. Selective inhibition of Sirtuin 2 achieves neuroprotection and identifies Sirtuin 2 to be a potential therapeutic avenue in Huntington's and Parkinson's disease. Biological Activity: HDAC activity. Sequence: Human sirtuin 2 (aa 2-389) is fused at the N-terminus to a His-tag. Storage and Stability: Short-term Storage: +4 degrees C Long-term Storage: -20 degrees C Working aliquots are stable for up to 3 months when stored at -20 degrees C.
Catalogue number: 045294
Size: 10ug
Form: 0.2um-filtered solution in 50mM TRIS-Cl, pH 8.2, 100mM NaCl.
Purity: >90% (SDS-PAGE)
Alternative names: SIRT2, NAD-dependent Deacetylase Sirtuin-2, SIR2-like protein 2, SIR2L2

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