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Sirtuin 7, Recombinant, Human (His) (SIRT7, NAD-dependent Deacetylase Sirtuin-7, SIR2-like Protein 7, SIR2L7)

Cat no: 045302

Sirtuin 7, Recombinant, Human (His) (SIRT7, NAD-dependent Deacetylase Sirtuin-7, SIR2-like Protein 7, SIR2L7)

Sirtuin 7 (SIRT7) is a NAD-dependent protein deacetylase. It is required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis. It promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. Sirtuin 7 is an essential regulator of tissue homeostasis in the heart. Sirt7-deficient animals undergo a reduction in mean and maximum lifespans and develop heart hypertrophy and inflammatory cardiomyopathy. Sirt7 interacts with p53 and efficiently deacetylates p53 in vitro, which corresponds to hyperacetylation of p53 in vivo and an increased rate of apoptosis in myocardium.\n\nBiological Activity:\nHDAC activity.\n\nSequence:\nHuman sirtuin 7 (aa 1-400) is fused at the N-terminus to a His-tag.\n\nStorage and Stability:\nShort-term Storage: +4 degrees C\nLong-term Storage: -20 degrees C\nWorking aliquots are stable for up to 3 months when stored at -20 degrees C.

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SPECIFICATIONS

Catalog Number

045302

Size

10ug

Form

0.2um-filtered solution in 55mM TRIS-Cl, pH 8.2, 150mM NaCl and 1mM DTT.

Purity

>90% (SDS-PAGE)

Alternative Names

SIRT7, NAD-dependent Deacetylase Sirtuin-7, SIR2-like Protein 7, SIR2L7

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