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SKP2 Polyclonal Antibody

Cat no: CAC07127

SKP2 Polyclonal Antibody

SKP2 Polyclonal Antibody

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SPECIFICATIONS

Price

323.00 USD

Catalog Number

CAC07127

Size

100 micro g

Applications

IHC, WB

Hosts

Rabbit

Conjugates

Unconj

Purity

Caprylic Acid Ammonium Sulfate Precipitation Purified

Target

SKP2

Clonality

Polyclonal

Storage Temp

Aliquot and store at -20 degrees C. Minimize freezing and thawing.

Research Area

For research use only. Not for diagnostic procedures.

Shipping Temp

Blue ice

Additional Info

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration.

Alternative Names

S-phase kinase-associated protein 2,Cyclin-A/CDK2-associated protein p45,F-box protein Skp2,F-box/LRR-repeat protein 1,p45skp2,SKP2,FBXL1

SUPPLIER INFO

Biomatik Corporation

Applications

ELISA

Reactivities

Hum

More info

Applications

ELISA

Reactivities

Hum

More info

Applications

ELISA

Reactivities

Hum

More info

Applications

ELISA

Reactivities

Hum

More info

Applications

ELISA

Reactivities

Hum

More info

Applications

ELISA

Reactivities

Hum

More info

Applications

ELISA

Reactivities

Hum

More info

Applications

ELISA

Reactivities

Hum

More info

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