Smad2 Antibody

Cat no: 250860

Supplier: ABBIOTEC

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Description
Additional Information

SMAD2 (Mothers against decapentaplegic homolog 2, SMAD 2,Mouse,others against DPP homolog 2) is a polypeptide that, as its name describes, is a homolog of the Drosophila gene: "Mothers against decepentaplegic". It belongs to the SMAD family of proteins, which belong to the TGF-(B) superfamily of modulators. Like many other TGF-(B) family members, SMAD2 is involved in cell signalling. SMAD2 modulates signals of activin and TGF-(B) proteins. It interacts with SMAD anchor for receptor activation (SARA). The binding of ligands causes the phosphorylation of the SMAD2 protein and the dissociation from SARA and the association with SMAD4. It is subsequently transferred to the nucleus where it forms comple, Xenopus/Amphibian,es with other proteins and acts as a transcription factor. SMAD2 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase.

Catalogue number:	250860
Reactivities:	Human, Mouse, Chicken/Bird, Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	Q15796
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Smad2.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit IgG
Additional info:	SMAD2; Mothers against decapentaplegic homolog 2; Mothers against DPP homolog 2; Mad-related protein 2; hMAD-2; MADH2; MADR2