Smad7 Antibody

Cat no: 251212

Supplier: ABBIOTEC

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Description
Additional Information

Mothers against decapentaplegic homolog 7 (Smad7) is an antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members. Smad7 has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Smad7 functions as an adapter to recruit SMURF2 to the TGF-beta receptor comple, Xenopus/Amphibian,. Smad7 also acts by recruiting the PPP1R15A-PP1 comple, Xenopus/Amphibian, to TGFBR1, which promotes its dephosphorylation. Genetic variations in Smad7 influence susceptibility to colorectal cancer type 3 (CRCS3). Colorectal cancer consists of tumors or cancer of either the colon or rectum or both.

Catalogue number:	251212
Reactivities:	Human, Mouse, Bovine, Porcine, Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	O15105
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Smad7.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit Ig
Additional info:	Smad7; Mothers against decapentaplegic homolog 7; Mothers against DPP homolog 7; hSMAD7; MADH7