SMC1 (5B6) Antibody

Cat no: 252952

Supplier: ABBIOTEC

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Description
Additional Information

SMC1 (Structural maintenance of chromosomes protein 1A) protein is involved in chromosome cohesion during cell cycle and in DNA repair. Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein comple, Xenopus/Amphibian, is required for sister chromatid cohesion. This comple, Xenopus/Amphibian, is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or SMC1. Most of the cohesin comple, Xenopus/Amphibian,es dissociate from the chromosomes before mitosis, although those comple, Xenopus/Amphibian,es at the kinetochore remain. Therefore, SMC1is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair.

Catalogue number:	252952
Reactivities:	Human
Applications:	Immunofluorescence, Immunohistochemistry
Size:	0.1 ml
Accession:	Q14683
Antigen:	Purified recombinant fragment of human SMC1 e, Xenopus/Amphibian,pressed in E. coli.
Format:	Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
P type:	Mouse Monoclonal Antibody
Isotype:	Mouse IgG1
Clonality:	5B6
Additional info:	Structural maintenance of chromosomes protein 1A; SMC protein 1A; -1-alpha; SMC-1A; Sb1.8; SMC1L1; D, Xenopus/Amphibian,S423E; KIAA0178; SB1.8; SMC1; SMC1A