SMI-4a ((5E/Z)-methylene]-2,4-thiazolidinedione)

Selective inhibitor of Pim-1 and Pim-2 protein kinases. Inducer of G1 phase cell cycle arrest. Inducer of p27Kip1. Inducer of apoptosis through the mitochondrial pathway. Inhibitor of the mammalian target of rapamycin C1 (mTORC1) pathway. Downregulates c-myc. Inhibitor of PRAS40 phosphorylation and mTOR activity. Potential anti-cancer compound. Blocks prostate cancer growth.\n\nStorage and Stability:\nShort-term Storage: +4 degrees C\nLong-term Storage: -20 degrees C\nStable for at least 2 years after receipt when stored at -20 degrees C.

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SPECIFICATIONS

Catalog Number

045305

Size

5mg

Purity

>95% (NMR)

References

Product Reference: \n?Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases: Z. Xia, et al.; J. Med. Chem. 52, 74 (2009)\n?Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells: Z. Beharry, et al.; Mol. Cancer Ther. 8, 1473 (2009)\n?PIM1 protein kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells: F. Zhang, et al.; Cancer Biol. Ther. 8, 846 (2009)\n?A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma: Y.-W. Lin, et al.; Blood 115, 824 (2010)\n?Regulation of Skp2 levels by the Pim-1 protein kinase: B. Cen, et al.; JBC 285, 29128 (2010)\n?

Alternative Names

(5E/Z)-methylene]-2,4-thiazolidinedione