SMO (Smoothened Homolog, Protein Gx, SMOH)

Cat no: S1014-63E4

Supplier: United States Biological

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G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:1000 Western Blot: 0.1-0.3ug/ml, observed in human bone marrow lysates on ~60kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Catalogue number:	S1014-63E4
Reactivities:	Human, Mouse, Rat, Canine, Zebrafish/Fish
Hosts:	Goat
Applications:	ELISA, Western Blot
Size:	100ug
Form:	Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type:	Pab
Purity:	Purified by immunoaffinity chromatography.
References:	1. Taipale J, Cooper MK, Maiti T, Beachy PA. Patched acts catalytically to suppress the activity of Smoothened. Nature. 2002 Aug 22;418(6900):892-7.
Additional info:	Recognizes human SMO. Species sequence homology: Canine, mouse, rat and zebrafish.

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SMO (Smoothened Homolog, Protein Gx, SMOH)

Cat no: S1014-63E4

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