SNAI2 (snail homolog 2 (Drosophila), MGC10182, Neural crest transcription factor Slug, Protein snail homolog 2, SLUG, SLUGH, SLUGH1, WS2D, Zinc finger protein SNAI2)

SNAI2 (snail homolog 2) is a neurogenic transcription factor belonging to the SNAIL family and is implicated in both the epithelial-mesenchymal transition and cell survival, as well as in important morphogenetic processes during embryo development and tumor metastasis. Through studies done in chick embryo, this protein has also been identified in the neural crest and in mesodermal cells emigrating from the primitive streak. In addition, SNAI2 has been found to be a key contributor to the function of the stem cell factor/c-kit signaling pathway, and mediates the radioresistance biological function of SCF/c-kit. Consequently, alterations to this gene have been associated to different human syndromes. SNAI2 is predominately expressed in placenta, melanocytes, and differentiating embryonic stem cells, as well as in adult heart, pancreas, liver, kidney, skeletal muscle.\n\nApplications:\nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1-2ug/ml\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

S1014-67M2

Size

100ug

Applications

WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in 0.1M Tris-Glycine, pH7.4, 150mM sodium chloride, 0.05% sodium azide.

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG1,k

References

1. Kusewitt, D., et al. (2009). J Invest Dermatol. 129(2):491-495. 2. Maurer, J., et al. (2008). PLoS ONE. 3(10):e3451. 3. Perez-Losada, J., et al. (2003). Oncogene. 22(27): 4205-4211. 4. Inoue, A., et al. (2002). Cancer Cell. 2(4):249-251. 5. Stegmann, K., et al. (1999). Mutat Res. 406(2-4):63-69.

Additional Info

Recognizes human SNAI2.