SNC80 ((+)-4-N,N-diethylbenzamide)

Highly selective and potent non-peptide delta-opioid receptor agonist. Mediates downregulation of the delta-opioid receptor. Shows antidepressant-like effects. Modulates voltage-dependent sodium channels. Antinociceptive. Activates ATP-sensitive K+ channels. Enhances amphetamine-mediated dopamine efflux.\n\nStorage and Stability:\nShort-term Storage: +4 degrees C\nLong-term Storage: +4 degrees C\nStable for at least 2 years after receipt when stored at +4 degrees C.

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SPECIFICATIONS

Catalog Number

045306

Size

5mg

Purity

>99% (NMR)

References

Product Reference: \n?Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4--N,N-diethylbenzamide (SNC 80): a highly selective, nonpeptide delta opioid receptor agonist: S.N. Calderon, et al.; J. Med. Chem. 37, 2125 (1994) \n?SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist: E.J. Bilsky, et al.; J. Pharmacol. Exp. Ther. 273, 359 (1995) \n?Structure-activity relationships for SNC80 and related compounds at cloned human delta and mu opioid receptors: R.J. Knapp , et al.; J. Pharmacol. Exp. Ther. 277, 1284 (1996) \n?Differential down-regulation of the human delta-opioid receptor by SNC80 andenkephalin: T. Okura, et al.; Eur. J. Pharmacol. 387, R11 (2000) \n?Potential anxiolytic and antidepressant-like activities of SNC80, a selective delta-opioid agonist, in behavioral models in rodents: A. Saitoh, et al.; J. Pharmacol. Sci. 95, 374 (2004) \n?Modulation of voltage-dependent sodium channels by the delta-agonist SNC80 in acutely isolated rat hippocampal neurons: C. Remy, et al.; Neuropharmacology 47, 1102 (2004) \n?Delta-opioid receptor agonist SNC80 induces peripheral antinociception via activation of ATP-sensitive K+ channels: D.F. Pacheco & I.D. Duarte; Eur. J. Pharmacol. 512, 23 (2005) \n?Antidepressant-like effects of the delta-opioid receptor agonist SNC80 (-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide) in an olfactory bulbectomized rat model: A. Saitoh, et al.; Brain Res. 1208, 160 (2008) \n?The selective delta opioid agonist SNC80 enhances amphetamine-mediated efflux of dopamine from rat striatum: K.E. Bosse, et al.; Neuropharmacology 55, 755 (2008)\n?

Alternative Names

(+)-4--N,N-diethylbenzamide