SNM1B (5' Exonuclease Apollo, DNA Cross-link Repair 1B Protein, SNM1 Homolog B, SNMIB, hSNM1B, DCLRE1B)

SNM1B, also known as DNA cross-link repair 1B protein, is a 532aa containing nuclear protein belonging to the DNA repair metallo-beta-lactamase (DRMBL) family. This DNA associated enzyme acts as a putative hydrolase and helps in V(D)J recombination and DNA repair of interstrand cross-links of DNA thus preventing strand separation and hence physically blocking transcription, replication, and segregation of DNA. SNM1B has the ability to localize to telomeres through an interaction with the shelterin component TERF2. SNM1B is important in ATM checkpoint activation, specifically after interstrand cross-links damage is correlated with its role in promoting double-strand break formation, and thus replication fork collapse. It interacts with the MRE11-RAD50-NBS1 (MRN) complex and with FANCDD2, further substantiating its role as a checkpoint or DNA repair protein.\n\nApplications:\nSuitable for use in Peptide ELISA. Other applications not tested.\n\nRecommended Dilutions:\nPeptide ELISA: 1:100-1:1000\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

S1014-95Q

Size

100ul

Applications

ELISA

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid, 0.025% sodium azide, 50% glycerol.

P Type

Pab

Purity

Serum

Isotype

IgG

References

1. Dronkert, MLG. et al. Molec. Cell. Biol. 20:4553-4561 (2000). 2. Demuth, I. et al. Oncogene. 23:8611-8618 (2004). 3. Chen, Y. et al. Science. 319:1092-1096 (2008).

Additional Info

Recognizes human SNM1B.