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SNRPF, aa1-86, Recombinant, Human (Small Nuclear Ribonucleoprotein Polypeptide F, snRNP-F, Sm Protein F, SmF, Sm-F, PBSCF)

Cat no: S1014-96W

SNRPF, aa1-86, Recombinant, Human (Small Nuclear Ribonucleoprotein Polypeptide F, snRNP-F, Sm Protein F, SmF, Sm-F, PBSCF)

Small nuclear ribonucleoprotein polypeptide F, also known SNRPF, belongs to the snRNP Sm proteins family. There are at least seven isoforms, E, F, G, D1, D2, D3 and B/B. This class of common proteins plays an essential role in the biogenesis of the snRNPs. In addition, these proteins represent the major targets for the so-called anti-Sm auto-antibodies which are diagnostic for systemic lupus erythematosus (SLE). SNRPF aid in the cytoplasmic construction of the UsnRNPs by binding to aconserved Sm site on UsnRNA and forming a stable snRNP core complex.\n\nSource:\nRecombinant corresponding to human SNRPF, fused to His-tag at N-terminus, expressed in E. coli.\n\nMolecular Weight: \n~11.8kD\n\nSequences of Amino Acids:\nMGSSHHHHHH SSGLVPRGSH MSLPLNPKPF LNGLTGKPVM VKLKWGMEYK GYLVSVDGYM NMQLANTEEY IDGALSGHLG EVLIRCNNVL YIRGVEEEEE DGEMRE\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

S1014-96W

Size

100ug

Form

Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, 1mM DTT, 1mM EDTA, 10% glycerol.

Purity

~95% (SDS-PAGE)

References

1. Brahms H., et al. (1997) Arthritis Rheum. 40:372-682. 2. Raker V A., et al. (1996) EMBO J. 15:2256-2269.

Alternative Names

Small Nuclear Ribonucleoprotein F

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