Supplier:
Alomone Labs Ltd.Cat no: RTS-500
SNX-482
SNX-482 is a peptidyl toxin originally isolated from venom of the spider Hysterocrates gigas Native SNX-482 blocks specifically Cav2.3 (a1E, R-type) channels in a voltage dependent manner. The block is reversible only upon application of strong voltage to facilitate unbinding. SNX-482 inhibits human Cav2.3 channels stably expressed in a mammalian cell line. An IC50 of 15-30 nM was obtained for block of Cav2.3 channel, using either patch clamp electrophysiology or K+-evoked Ca2+ flux. At low nanomolar concentrations, SNX-482 also blocked a native R-type Ca2+ current in rat neurohypophyseal nerve terminals, but concentrations of 200-500 nM had no effect on R-type Ca2+currents in several types of rat central neurons. SNX-482 was also used to demonstrate the contribution of Cav2. channels to transmitter release. Recently it was shown that higher concentrations of SNX-482 also block Cav2.1 channels in chromaffin cells.
Alomone Labs is pleased to offer SNX-482, a recombinant peptide expressed in and extracted from E. coli and purified to homogeneity.
Ion Channel Modulators; Voltage - Gated Ca2+ Channel Blockers.
Prices direct from Alomone Labs Ltd.
Quick response times
Exclusive Biosave savings/discounts
SPECIFICATIONS
Catalog Number
RTS-500
Size
5 micro g
Purity
>98%
Concentration
10-100 nM.
Shipping Temp
Room Temperature
Molecular Weight
4495 da
More from Alomone Labs Ltd.
Latest promotions
Spend less time on DNA cleanup so you can do more science. The MSB Spin PCRapace is the fastest way to purify your DNA from PCR, restriction digestion, and...
Genovis introduces GlycINATOR™• Works on most IgGs• Effective on high-mannose and bisected N-linked Fc-glycans • Rapid – 30-minute...
Use promo code EASY3 to receive 13% off and FREE shipping!Experience a new dimension of electronic pipetting with the NEW Easypet 3 pipette controller. The...
New brilliant antibodies, and new lower prices!For flow cytometry reagents in general, \"bright is better.\" The violet-excitable BD Horizon™ BV421 and...
As an incentive to qualify our BSA, we are offering a 20% discount when you purchase your first 100g, 500g or 1000g of any grade of Bovine Serum Albumin....
It is not every day that you are given something for nothing. We are giving away additional spectrophotometer software.Cecil Instruments have enhanced the...
We're so sure that you'll prefer Cayman Assay kits over your present brand that we're willing to give you a free assay kit to prove it!
For the past decade scientists have extensively used ATS secondary toxin conjugates to make their own targeted toxins for in vitro use.The ability to combine...
10% Discount on 2 Rabbit Polyclonal Antibody Service. With over 20 years experience, SDIX has developed into the premier US custom antibody producer,...
Did your supplier increase the price of Fetal Bovine Serum? Did they substitute the US Origin with USDA? Well say no more! Innovative Research is still...
Bulk Cytokines with Custom Vialing.20 - 50% off cytokines, growth factors, chemokines and more...For a limited time Cell Sciences is offering substantial...
Jenway’s 73 series spectrophotometer range provides four models with a narrow spectral bandwidth of 5nm and an absorbance range of –0.3 to 2.5A,...
Are you planning to have a customised antibody made for your research?Since 2000, Everest has been producing a catalog containing thousands of affinity...
Top suppliers
Carl Zeiss Microscopy
27 products
Eppendorf
1 products
Promega Corporation
11 products
Panasonic Healthcare Company
5 products
Life Technologies
1 products
Nikon Instruments Europe
11 products
Olympus Europa Holding GmbH
3 products
Leica Microsystems, Inc.
10 products
GE Healthcare Life Sciences
2 products
Tecan Trading AG
19 products
Beckman Coulter, Inc.
1 products
United States Biological
230753 products
AB SCIEX
3 products
BD (Becton, Dickinson and Company)
1 products
RANDOX TOXICOLOGY
5 products
Randox Food Diagnostics
6 products