SOCS-1 Antibody

Cat no: 250862

Supplier: ABBIOTEC

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Description
Additional Information

SOCS family proteins form part of a classical negative feedback system that that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs it inhibits their kianse activity. In vitro, they also supresses Tec protein-tyrosine activity. SOCS1 appears to be a major regulator of interleukin 6 (IL6) and leukemia inihibitory factor (LIF) signaling. SOCS-1 regulates interferon-gamma mediated sensory neuron survival. It is also implicated, through SOCS bo, Xenopus/Amphibian, binding, in ubiquitin-dependent protein degradation. There is high e, Xenopus/Amphibian,pression in thymus, and lower e, Xenopus/Amphibian,pression in lung and spleen.

Catalogue number:	250862
Reactivities:	Human, Mouse, Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	O15524
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human SOCS-1.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit IgG
Additional info:	Socs 1; SOCS-1; Suppressor of cytokine signaling 1; JAK-binding protein; JAB; STAT-induced STAT inhibitor 1; SSI-1; Tec-interacting protein 3; SOCS1