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SOCS-3, Recombinant, Human (His) (CIS-3, Cytokine-inducible SH2-containing Protein-3, SSI-3, Suppressor of Cytokine Signaling-3, SOCS 3)

SOCS-3, Recombinant, Human (His) (CIS-3, Cytokine-inducible SH2-containing Protein-3, SSI-3, Suppressor of Cytokine Signaling-3, SOCS 3)

Cat no: 045307

Supplier: United States Biological
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SOCS-3 is an SH2-containing protein predominantly expressed in T-helper type 2 cells, that binds to the activation loop of Janus kinases, inhibiting the kinase activity and thereby suppressing cytokine signaling. SOCS-3 therapy may be useful in the treatment of cancer. SOCS-3 has an important role in regulating the onset and maintenance of TH2-mediated allergic immune disease and is a new therapeutic target for antiallergic drugs. Sequence: Human SOCS-3 (aa 1-225) is fused at the C-terminus to a His-tag. Storage and Stability: Short-term Storage: +4 degrees C Long-term Storage: -20 degrees C Working aliquots are stable for up to 3 months when stored at -20 degrees C.
Catalogue number: 045307
Size: 50ug
Form: 0.2um-filtered solution in 20mM sodium phosphate, pH 6.5, 20mM NaCl, 50mM glutamate, 50mM arginine, 2mM dithiothreitol, 1mM EDTA.
Purity: >90% (SDS-PAGE)
Alternative names: CIS-3, Cytokine-inducible SH2-containing Protein-3, SSI-3, Suppressor of Cytokine Signaling-3, SOCS 3

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