SOCS1, CT (Suppressor of Cytokine Signaling 1, Tec-interacting Protein 3, TIP-3, STAT-induced STAT Inhibitor 1, SSI-1, JAK-binding Protein, JAB, Suppressor of Cytokine Signaling 1, SOCS-1, SSI1, TIP3)

Suppressors of cytokine signaling (SOCS) protein family includes eight members in humans: SOCS-1 through SOCS-7 and cytokine-inducible Src-homology 2 (SH2) containing protein (CIS). All members of the family have similar structure: variable length (50-380aa) and aa sequence N-terminal region, SH2 domain in the center, and homologous C-terminal 40aa long sequence that was named SOCS box. Studies have demonstrated that animals lacking normal SOCS function exhibit high cytokine activity that leads to a variety of inflammatory and autoimmune diseases and even cancer. SOCS-1 is 211aa long and shares sequence similarity with SOCS-3. Its expression in many tissues is induced by elevated levels of IL-2, IL-3, IL- 6, IL-13, LIF, GM-CSF, IFNg, GH, and prolactin. SOCS-1 targets Janus activated kinases 1-3 (JAK1-3) and tyrosine kinases 2 (TYK2). These events negatively regulate family of signal transducer and activator of transcription (STAT) proteins. For example, SOCS-1 binds to Y1007 residue of JAK2 and blocks its phosphorylation activity that does not allow activation of STAT3.\n\nApplications:\nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nELISA: 0.1-1ug/ml\nWestern Blot: 1-2ug/ml\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

S1040-01V

Size

50ug

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in PBS, 0.1% BSA, 0.05% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Hilton, D. J. et al. Biochemistry 195, 114 (1998). 2. Krebs, D. et al. Stem Cells 19, 378 (2001). 3. Bullock, A. N. et al. Structure 15, 1493 (2007). 4. Cooney, R. N. et al. Shock 17, 83 (2002). 5. Waiboci, L.W. et al. J Immun 178, 5058 (2007).

Additional Info

Recognizes human SOCS-1. Species Crossreactivity: mouse and rat.