Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 11 (Solute Carrier Family 7 Member 11, SLC7A11, Amino Acid Transport System xc xCT, Calcium Channel Blocker Resistance Protein CCBR1, Cystine/glutamate Transporter, xCT)

Mammalian amino acid transport systems consist of a large variety of transporters. The amino acid transporter, cystine/glutamic acid transporter xCT, for system xc has been proposed to be responsible for the cystine transport through the plasma membrane. System xc mediates an amino acid exchange and prefers cystine and glutamate as its substrates. The transporter designated as xCT requires 4F2 heavy chain (4F2hc:CD98) for its functional expression, and belongs to the family of amino acid transporters that associates with the type II membrane glycoproteins such as 4F2hc. In brain, it has been proposed that system xc is up-regulated in glial cells upon oxidative stress and plays an essential roles to protect neurons against oxidative stress. Recent studies have implicated xCT as a gateway that Kaposi's sarcoma Herpes virus (KSHV) uses to enter cells.\n\nApplications: \nSuitable for use in Western Blot and Immunohistochemistry (paraffin-embedded sections). Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nPositive Control: Stomach tissue lysate\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

S5329-08C

Size

100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Form

Tris-glycine with 150mM NaCl

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

References

1. Liu, R., et al. Cystine-Glutamate Transporter SLC7A11 Mediates Resistance to Geldanamycin, but Not to 17-(Allylamino)-17-demethoxygeldanamycin. Mol. Pharmacol., Dec 2007;72:1637-1646.

Additional Info

This antibody is specific for XCT. Species Crossreactivity: This antibody reacts with the human and mouse proteins. Other species have not been tested.