Solute Carrier Family 7 Member 5 (SLC7A5, 4F2 Light Chain, 4F2 LC, 4F2LC, CD98 Light Chain, CD98LC, Integral Membrane Protein E16, Large Neutral Amino Acids Transporter Small Subunit 1, L-type Amino Acid Transporter 1, LAT1, hLAT1, MPE16, Y+ System Cation

Involved in amino acid metabolism, transport, and permease activity. Transmembrane protein that may be preferentially expressed in primary breast tumor cells.\n\nApplications:\nSuitable for use in Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nImmunohistochemistry (paraffin): 20ug/ml\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nHuman terminal villi\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

S5329-07H

Size

50ug

Applications

IHC

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.7, 0.1% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Anticancer Res 2006 Jul. 26:2943-8 The RNA interference of amino acid transporter LAT1 inhibits the growth of KB human oral cancer cells. Kim CH, Park KJ, Park JR, Kanai Y, Endou H, Park JC, and Kim do K.\n2. Anticancer Res 2006 May. 26:1989-96 Differential expression and functional characterization of system L amino acid transporters in human normal osteoblast cells and osteogenic sarcoma cells. Kim SG, Kim HH, Kim HK, Kim CH, Chun HS, Kanai Y, Endou H, and Kim do K. 3. J Clin Oncol 2006 Jul. 24:3039-47 Novel prognostic immunohistochemical biomarker panel for estrogen receptor-positive breast cancer. Ring BZ, Seitz RS, Beck R, Shasteen WJ, Tarr SM, Cheang MC, Yoder BJ, Budd GT, Nielsen TO, Hicks DG, Estopinal NC, and Ross DT. 4. Int J Cancer 2006 Feb.: L-type amino acid transporter 1 as a potential molecular target in human astrocytic tumors. Nawashiro H, Otani N, Shinomiya N, Fukui S, Ooigawa H, Shima K, Matsuo H, Kanai Y, and Endou H. 5. Biochim Biophys Acta 2006 Feb.: Functional and molecular characterization of adenosine transport at the rat inner blood-retinal barrier. Nagase K, Tomi M, Tachikawa M, and Hosoya KI.

Additional Info

Recognizes human CD98.

Alternative Names

Solute Carrier Family 7 (Cationic Amino Acid Transporter, y+ System), Member 5, D16S469E