Somatostatin Receptor Type 2, aa341-352, Human (SSTr2)

The sequence CSDSKQDKSRLNE (linear) represents amino acids 341-352 of somatostatin receptor 2. An additional cysteine has been conjugated to the N-terminus.\n\nSomatostatin family of receptors has five members SSTr1-SSTr5 as well as two isoforms of somatostatin receptor 2, SSTr2A and SSTr2B. They are coupled to G protein and are involved in regulation of numerous processes including secretion of insulin, glucagons and growth hormone, cell growth induced by bFGF and excitation of neurons in central and peripheral nervous system. They are activated by somatostatin secreted by endocrine and nerve cells and are known to be involved in a wide range of tumors including that of breast, prostrate, pancreas. In rat central nervous system Somatostatin receptor 1 is primarily localized to axons and therefore may function in a presynaptic manner. \n\nSomatostatin acts to regulate numerous physiological processes by binding to and activating specific receptors in target tissues. Activation of these receptors by somatostatin, which is secreted by nerve and endocrine cells, regulates the secretion of insulin, glucagon and growth hormone, neuronal excitability in both the brain and the peripheral nervous system, and cell growth. Somatostatin receptors have been implicated in numerous diseases ranging from Alzheimer's to cancers of the gastrointestinal tract, breast, prostate, and pituitary. Somatostatin Receptor 1 (SSTr1), along with SSTr2, is expressed at the highest levels in the stomach and jejunum, cerebrum and kidney, respectively.\n\nSomatostatin was originally isolated from the hypothalamus and characterized by its ability to inhibit release of growth hormone from the pituitary gland. It exists in two forms, somatostatin-14, composed of 14 amino acids and somatostatin-28, a prohormone composed of 28 residues.\n\nApplications: \nSuitable for use in ELISA. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability: \nLyophilized powder may be stored at 4 degrees C for short-term only. Stable for 12 months at -20 degrees C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.\n\n\n

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