Somatostatin

Somatostatin was originally isolated from the hypothalamus. It was characterized by its ability to inhibit release of growth hormone from the pituitary gland. It exists in two forms, somatostatin-14, composed of 14 amino acids and somatostatin-28, a prohormone composed of 28 residues. The Somatostatin antibody will label D cells of the endocrine mammalian pancreas and cells of the hypothalamic parvicellular region. It may prove useful for the identification of tumors and hyperplasias of the pancreatic islets.\n\nApplications:\nSuitable for use in Immunohistochemistry. Other applications have not been tested.\n\nRecommended Dilutions:\nImmunohistochemistry: 1:50-1:100 on human brain.\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile ddH2O. 0.05% thimerosal. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

S5331-13

Size

100ul

Applications

IHC

Hosts

Rat

Reactivities

Hum

Form

Supplied as a lyophilized powder. Reconstitute with 1ml sterile ddH2O, 0.05% thimerosal.

P Type

Mab

Purity

Supernatant

Isotype

IgG2b

References

1. Neurochemistry: Modern methods and applications pp. 59-74 (1998). 2. Immunological Reviews 100: 279-306 (1987). 3. PNAS USA 91: 2955-2959 (1994). 4. J. Neuroscience 16: 2701-2715 (1996). 5. J. Neuroscience 18: 1056-1071 (1998). 6. J. Neuroscience 18(17): 6963-6976 (1998). 7. Pancreas 18: 53-64 (1999).

Additional Info

Recognizes human Somatostatin. Partial crossreactivity with somatostatin fragments. Does not crossreact with enkephalins, other endorphins, substance P or CGRP.