SORL1 (Sortilin-related Receptor L(DLR class) A Repeats Containing, gp250, Low Density Lipoprotein Receptor Relative with 11 Ligand Binding Repeats, LDLR Relative with 11 Ligand Binding Repeats, LR11, LRP9, Mosaic Protein LR11, SorLA-1, Sortilin-related R

SORL1 is likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. It binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. SORL1 binds the receptor-associated protein (RAP). It could play a role in cell-cell interaction. SORL1 is expressed mainly in brain, where it is most abundant in the cerebellum, cerebral cortex and the occipital pole; low expression in the putamen and the thalamus. It is also found in spinal cord, testis, liver, kidney and pancreas with detectable levels in placenta, lung and heart. Moreover, it is expressed in the prostate, ovary, thyroid and spleen, but not found in kidney, liver, lung, skeletal muscle, bone marrow and adrenals.\n\nApplications: \nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nCellular Localization: Type I membrane protein\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

S5353-02A

Size

100ug

Applications

ELISA, WB

Hosts

Goat

Reactivities

Hum, Mouse, Rabbit

Form

Supplied as a liquid in TBS, pH 7.2, 0.5% BSA.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

Jacobsen L et al. Activation and functional characterization of the mosaic receptor SorLA/LR11. J Biol Chem 276:22788-96 (2001). <PUBMED:11294867>

Additional Info

Species Crossreactivity: Expected to crossreact with Human (100% identity with immunogen), Mouse (100% identity with immunogen) and Rabbit (100% identity with immunogen) due to sequence homology.