SOS1 (Son of Sevenless Homolog 1, SOS-1)

Supplier:

United States Biological

Cat no: S5360-18A

SOS1 (Son of Sevenless Homolog 1, SOS-1)

SOS1 (son of sevenless homolog 1) is a ubiquitously expressed 150kD intracellular protein and bifunctional guanine nucleotide exchange factor (GEF), which plays a role in growth and differentiation signalling pathways and in actin reorganization, by acting as a regulator of Ras and Rac/Rho GTPases. Mutations in the SOS1 gene are responsible for the rare oral overgrowth condition known as gingival fibromatosis 1 (GINGF1), and also the cause of the relatively common autosomal dominant disorder Noonan syndrome type 4 (NS4), characterized by short stature, congenital heart malformation, bleeding diathesis and distinctive facial features.\n\nApplications:\nSuitable for use in ELISA, Immunofluorescence and Western Blot. Other applications not tested. \n\nRecommended Dilutions:\nWestern Blot: 1ug/ml Detects a band of ~150kD in K562 and RAJI cell lysates under reducing conditions.\nOptimal dilutions to be determined by the researcher. \n\nRecommended secondary antibodies:\nI1904-06C: IgG, H&L (HRP) (X-Adsorbed) Pab Gt xMo\nI1904-06H: IgG, H&L (HRP) (X-Adsorbed) Pab Gt xMo\nI1904-14C: IgG, Fc (HRP) Pab Gt xMo\nI1904-19C: IgG, F(ab

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

S5360-18A

Size

100ug

Applications

ELISA, IF, WB

Hosts

Mouse

Reactivities

Hum, Mouse

Form

Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.

P Type

Mab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG1

References

1. Scita, G. et al. (2000) Signaling from Ras to Rac and beyond: not just a matter of GEFs. EMBO J. 19: 2393-2398.

Additional Info

Recognizes human Son of Sevenless 1. Species Crossreactivity: mouse

Read more on Supplier website

SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

More from
United States Biological

All suplier products

United States Biological

FSD2, NT (FSD2, SPRYD1, Fibronectin type III and SPRY domain-containing protein 2, SPRY domain-containing protein 1) (FITC)

Applications

ELISA, IHC, WB

Hosts

Rabbit

Reactivities

Hum

United States Biological

POU6F2, NT (POU6F2, RPF1, POU domain, class 6, transcription factor 2, Retina-derived POU domain factor 1) (FITC)

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

United States Biological

CEACAM18, NT (CEACAM18, Carcinoembryonic antigen-related cell adhesion molecule 18) (FITC)

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

United States Biological

LIPC, ID (LIPC, HTGL, Hepatic triacylglycerol lipase, Lipase member C) (FITC)

Applications

ELISA, FC, IHC, WB

Hosts

Rabbit

Reactivities

Hum

United States Biological

GNE, NT (GNE, GLCNE, Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, UDP-GlcNAc-2-epimerase/ManAc kinase, UDP-N-acetylglucosamine 2-epimerase, UDP-GlcNAc-2-epimerase, Uridine diphosphate-N-acetylglucosamine-2-epimerase, N-acet

Applications

ELISA, IHC, WB

Hosts

Rabbit

Reactivities

Hum

United States Biological

TNFSF4, ID (TNFSF4, TXGP1, Tumor necrosis factor ligand superfamily member 4, Glycoprotein Gp34, OX40 ligand, TAX transcriptionally-activated glycoprotein 1, CD252) (FITC)

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

United States Biological

F2RL2, NT (F2RL2, PAR3, Proteinase-activated receptor 3, Coagulation factor II receptor-like 2, Thrombin receptor-like 2) (FITC)

Applications

ELISA, IHC, WB

Hosts

Rabbit

Reactivities

Hum

United States Biological

GBA3, CT (GBA3, CBG, CBGL1, Cytosolic beta-glucosidase, Cytosolic beta-glucosidase-like protein 1) (FITC)

Applications

ELISA, IHC, WB

Hosts

Rabbit

Reactivities

Hum

Advertisehere

MtoZ Horizontal banner

Latest promotion FROM:

Latest promotions

Explore all promotions

B-Bridge International, Inc.

DNA Cleanup in 7 Minutes, 10% OFF

Spend less time on DNA cleanup so you can do more science. The MSB Spin PCRapace is the fastest way to purify your DNA from PCR, restriction digestion, and...

BD (Becton, Dickinson and Company)

Analyze your cells with more colors at lower prices!

New brilliant antibodies, and new lower prices!For flow cytometry reagents in general, \"bright is better.\" The violet-excitable BD Horizon™ BV421 and...

Europa Bioproducts Ltd

20% discount on Bovine Serum Albumin!

As an incentive to qualify our BSA, we are offering a 20% discount when you purchase your first 100g, 500g or 1000g of any grade of Bovine Serum Albumin....

Cecil Instruments Limited

Cecil Spectrophotometer Enhancements for Free!

It is not every day that you are given something for nothing. We are giving away additional spectrophotometer software.Cecil Instruments have enhanced the...

Cayman Chemical Company

Cayman Challenge

We're so sure that you'll prefer Cayman Assay kits over your present brand that we're willing to give you a free assay kit to prove it!

SDIX

Custom Polyclonal Antibodies

10% Discount on 2 Rabbit Polyclonal Antibody Service. With over 20 years experience, SDIX has developed into the premier US custom antibody producer,...

Advanced Targeting Systems, Inc.

Secondary Conjugates - Save 20%

For the past decade scientists have extensively used ATS secondary toxin conjugates to make their own targeted toxins for in vitro use.The ability to combine...

Innovative Research, Inc

Premium US Origin Fetal Bovine Serum for only $95 per 500ml!

Did your supplier increase the price of Fetal Bovine Serum? Did they substitute the US Origin with USDA? Well say no more! Innovative Research is still...

Cell Sciences, Inc.

Recombinant Proteins

Bulk Cytokines with Custom Vialing.20 - 50% off cytokines, growth factors, chemokines and more...For a limited time Cell Sciences is offering substantial...

Bibby Scientific

73 series spectrophotometer

Jenway’s 73 series spectrophotometer range provides four models with a narrow spectral bandwidth of 5nm and an absorbance range of –0.3 to 2.5A,...

Everest Biotech Ltd

Custom antibody for $300

Are you planning to have a customised antibody made for your research?Since 2000, Everest has been producing a catalog containing thousands of affinity...

Top suppliers

Explore all suppliers

United States Biological

230753 products

Carl Zeiss Microscopy

27 products

Promega Corporation

11 products

Panasonic Healthcare Company

5 products

Life Technologies

1 products

Nikon Instruments Europe

11 products

Olympus Europa Holding GmbH

3 products

Leica Microsystems, Inc.

10 products

GE Healthcare Life Sciences

2 products

Tecan Trading AG

19 products

Beckman Coulter, Inc.

1 products

AB SCIEX

3 products

BD (Becton, Dickinson and Company)

1 products

RANDOX TOXICOLOGY

5 products

Randox Food Diagnostics

6 products