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Sox 2, Recombinant, Human (SOX2, SOX-2, Sex Determining Region Y-box 2, SRY (Sex Determining Region Y) Box 2, ANOP3, MCOPS3, MGC2413, Transcription Factor SOX2)

Cat no: S5364-11J

Sox 2, Recombinant, Human (SOX2, SOX-2, Sex Determining Region Y-box 2, SRY (Sex Determining Region Y) Box 2, ANOP3, MCOPS3, MGC2413, Transcription Factor SOX2)

SRY (sex determining region Y)-box 2, also known as SOX2, is a transcription factor that is essential to maintain self-renewal of undifferentiated embryonic stem cells. This Protein is a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Recombinant human SOX2 protein was expressed in E. coli.\n\nSource: \nRecombinant corresponding to aa1-200 of human SOX2 6x His tagged expressed in E. coli.\n\nAA Sequence:\nMYNMMETELK PPGPQQTSGG GGGNSTAAAA GGNQKNSPDR VKRPMNAFMV WSRGQRRKMA QENPKMHNSE ISKRLGAEWK LLSETEKRPF IDEAKRLRAL HMKEHPDYKY RPRRKTKTLM KKDKYTLPGG LLAPGGNSMA SGVGVGAGLG AGVNQRMDSY AHMNGWSNGS YSMMQDQLGY \nPQHPGLNAHG AAQMQPMHRY LEHHHHHH\n\nApplications: \nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

S5364-11J

Size

100ug

Applications

WB

Form

Supplied as a liquid in 20mM Tris HCl, pH 8.0, 200mM NaCl, 2mM DTT, 40% glycerol.

Purity

~ 90% (SDS-PAGE). Purified by using conventional chromatography techniques.

References

1. Wei Z., et al. (2009) Stem Cells. 27(12):2969-78. 2. Martinez-Fernandez A., et al. (2009) Circ Res. 25; 105(7):648-56.

Alternative Names

SRY-related HMG Box 2

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