Sox 6 (SOX6, SOX-6, SRY Sex Determining Region Y Box 6, SRY (Sex Determining Region Y)-box 6, HSSOX 6, HSSOX6, SRY-box 6, SRY Box Containing Gene 6, Transcription Factor SOX6, Transcription Factor SOX-6)

Supplier:

United States Biological

Cat no: S5364-23D

Sox 6 (SOX6, SOX-6, SRY Sex Determining Region Y Box 6, SRY (Sex Determining Region Y)-box 6, HSSOX 6, HSSOX6, SRY-box 6, SRY Box Containing Gene 6, Transcription Factor SOX6, Transcription Factor SOX-6)

The SOX (SRY-box containing gene) gene family encodes a group of transcription factors defined by the conserved high motility group (HMG) DNA-binding domain.\nSOX6 is a transcriptional factor that is specifically expressed in the developing central nervous system and in the early stages of chondrogenesis in mouse embryos. Results indicate that the developmentally regulated transcription factor SOX6 is aberrantly expressed in glioma.\n\nApplications: \nSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nCellular Localization: Nuclear\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

S5364-23D

Size

50ug

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

50% Ammonium sulfate, PBS

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Iguchi H et al. SOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice. J Biol Chem 280:37669-80 (2005). PubMed: 16148004

Additional Info

Species Crossreactivity: This antibody is reactive against human, mouse, rat and primate.

Read more on Supplier website

SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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